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血液病医院

  • 姓 名:

    饶书权

  • 单 位:

    中国医学科学院血液学研究所(血液病医院)

  • 教职岗位:

    助理教授

  • 聘任时间:

    2021-07-29

  • 一级学科:

    临床医学

  • 二级学科:

    干细胞与再生医学

  • 联系方式:

    raoshuquan@ihcams.ac.cn

  • 导师风采链接:

个人简介

饶书权,1987年生,籍贯四川,分子生物学家,中国医学科学院血液学研究所研究员,博士生导师。2006年考入华中科技大学药学专业,2010年获得学士学位。2010年在北京协和医学院基础学院生物化学与分子生物学专业攻读博士学位,从事复杂疾病的遗传学和发病机制研究。2017年开始分别在圣裘德儿童研究医院和哈佛医学院波士顿儿童医院进行博士后研究工作,主要研究基因编辑的技术研发和骨髓衰竭性疾病的发病机理。 2021年7月聘为研究员,博士生导师。


主要研究方向

新型基因编辑工具的开发;CRISPR高通量筛选与功能基因组;遗传性疾病的基因治疗。


代表性成果

皇冠足球90比分

图片

1. Fuquan Zhang#*, Shuquan Rao#, Hongbao Cao, Xiangrong Zhang, Qiang Wang, Yong Xu, Jing Sun, Chun Wang, Jiu Chen, Xijia Xu, Ning Zhang, Lin Tian, Jianmin Yuan, Guoqiang Wang, Lei Cai, Mingqing Xu# and Ancha Baranova#. Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder. J Clin Invest 2022;132(3):e145942. (IF=19.46)

2. Shuquan Rao#, Ancha Baranova#, Hongbao Cao, Jiu Chen, Xiangrong Zhang, Fuquan Zhang*. Genetic mechanisms of COVID-19 and its association with smoking and alcohol consumption. Brief Bioinform 2021;22(6):1–12. (IF=13.99)

3. Yao Hu#, Adrienne M Stilp#, Caitlin P McHugh#, Shuquan Rao#, Deepti Jain, Xiuwen Zheng, John Lane, Sébastian Méric de Bellefon, Laura M Raffield, Ming-Huei Chen, Lisa R Yanek, Marsha Wheeler, Yao Yao, Chunyan Ren, Jai Broome, Jee-Young Moon, Paul S de Vries, Brian D Hobbs, Quan Sun, Praveen Surendran, Jennifer A Brody, Thomas W Blackwell, Hélène Choquet, Kathleen Ryan, Ravindranath Duggirala, Nancy Heard-Costa, Zhe Wang, Nathalie Chami, Michael H Preuss, Nancy Min, Lynette Ekunwe, Leslie A Lange, Mary Cushman, Nauder Faraday, Joanne E Curran, Laura Almasy, Kousik Kundu, Albert V Smith, Stacey Gabriel, Jerome I Rotter, Myriam Fornage, Donald M Lloyd-Jones, Ramachandran S Vasan, Nicholas L Smith, Kari E North, Eric Boerwinkle, Lewis C Becker, Joshua P Lewis, Goncalo R Abecasis, Lifang Hou, Jeffrey R O'Connell, Alanna C Morrison, Terri H Beaty, Robert Kaplan, Adolfo Correa, John Blangero, Eric Jorgenson, Bruce M Psaty, Charles Kooperberg, Russell T Walton, Benjamin P Kleinstiver, Hua Tang, Ruth J F Loos, Nicole Soranzo, Adam S Butterworth, Debbie Nickerson, Stephen S Rich, Braxton D Mitchell, Andrew D Johnson, Paul L Auer, Yun Li, Rasika A Mathias, Guillaume Lettre, Nathan Pankratz, Cathy C Laurie, Cecelia A Laurie, Daniel E Bauer, Matthew P Conomos, Alexander P Reiner*, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Am J Hum Genet 2021;108(5):874–893. (IF=11.04)

4. Shuquan Rao#, Yao Yao#, Josias Soares de Brito#, Qiuming Yao, Anne H Shen, Ruth E Watkinson, Alyssa L Kennedy, Steven Coyne, Chunyan Ren, Jing Zeng, Anna Victoria Serbin, Sabine Studer, Kaitlyn Ballotti, Chad E Harris, Kevin Luk, Christian S Stevens, Myriam Armant, Luca Pinello, Scot A Wolfe, Roberto Chiarle, Akiko Shimamura, Benhur Lee, Peter E Newburger, Daniel E Bauer*. Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. Cell Stem Cell 2021;28(5):833–845. (IF=25.27)

5. Shuquan Rao#*, Yao Yao#, Daniel E Bauer*. Editing GWAS: experimental approaches to dissect and exploit disease-associated genetic variation. Genome Med 2021;13(1):41. (IF=15.27)

6. Yao Yao#, Fei Ye#, Kailong Li#, Peng Xu, Wenjie Tan, Quansheng Feng, Shuquan Rao#*. Genome and epigenome editing identify CCR9 and SLC6A20 as target genes at the 3p21.31 locus associated with severe COVID-19. Signal Transduct Target Ther 2021;6(1):85. (IF=38.10)

7. Yao Yao#, Jia Yang, Qian Qin, Chao Tang, Zhidan Li, Li Chen, Kailong Li, Chunyan Ren, Lu Chen*, Shuquan Rao*. Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation. Commun Biol 2020;3(1):790. (IF=6.27)

8. Shuquan Rao#*, Na Luo#, Jing Sui, Qi Xu, Fuquan Zhang. Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population. Br J Psychiatry 2020;216(5):254-258. (IF=9.32)

9. Yao Yao#, Jia Yang#, Yimin Xie, Hai Liao, Baoying Yang, Qi Xu, Shuquan Rao*. No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia. Schizophr Bull 2020;46(3):603-611. (IF=9.31)

10. Zhihua Yang#, Shuang Zhang, Fuquan Zhang, Yao Yao, Kwangwoo Kim, David Meyre, Hongmei Zhang, Hai Liao, Shuquan Rao*, Xinhe Huang*. Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders. Signal Transduct Target Ther 2019;4;4:39. (IF=13.49)